Model Systems, Lipid Rafts, and Cell Membranes
نویسندگان
چکیده
منابع مشابه
Lipid rafts reconstituted in model membranes.
One key tenet of the raft hypothesis is that the formation of glycosphingolipid- and cholesterol-rich lipid domains can be driven solely by characteristic lipid-lipid interactions, suggesting that rafts ought to form in model membranes composed of appropriate lipids. In fact, domains with raft-like properties were found to coexist with fluid lipid regions in both planar supported lipid layers a...
متن کاملLipid rafts as functional heterogeneity in cell membranes.
Biological membranes are not structurally passive solvents of amphipathic proteins and lipids. Rather, it appears their constituents have evolved intrinsic characteristics that make homogeneous distribution of components unlikely. As a case in point, the concept of lipid rafts has received considerable attention from biologists and biophysicists since the formalization of the hypothesis more th...
متن کاملThe state of lipid rafts: from model membranes to cells.
Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, detergent solubili...
متن کاملThe molecular face of lipid rafts in model membranes.
Cell membranes contain a large number of different lipid species. Such a multicomponent mixture exhibits a complex phase behavior with regions of structural and compositional heterogeneity. Especially domains formed in ternary mixtures, composed of saturated and unsaturated lipids together with cholesterol, have received a lot of attention as they may resemble raft formation in real cells. Here...
متن کاملLipid rafts, detergent-resistant membranes, and raft targeting signals.
Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are oft...
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ژورنال
عنوان ژورنال: Annual Review of Biophysics and Biomolecular Structure
سال: 2004
ISSN: 1056-8700,1545-4266
DOI: 10.1146/annurev.biophys.32.110601.141803